{"id":5930,"date":"2017-11-24T15:57:43","date_gmt":"2017-11-24T15:57:43","guid":{"rendered":"http:\/\/www.parkinson.ca\/research-fr\/projets-de-2016-2018\/discovering-the-role-one-tiny-protein-plays-in-causing-parkinsons-disease\/"},"modified":"2017-11-24T16:09:32","modified_gmt":"2017-11-24T16:09:32","slug":"discovering-the-role-one-tiny-protein-plays-in-causing-parkinsons-disease","status":"publish","type":"page","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/recherche\/2016-2018-projets-de-recherche\/discovering-the-role-one-tiny-protein-plays-in-causing-parkinsons-disease\/","title":{"rendered":"Comprendre le r\u00f4le que joue une toute petite prot\u00e9ine dans l\u2019apparition de la maladie de Parkinson"},"content":{"rendered":"
\n\"\"Eric Shoubridge, professeur
\nUniversité McGill
\nSubventions pour projets pilotes
\n45 000 $ sur 1 an<\/p>\n

Disponible seulement en Anglais<\/p>\n

Role of the mitochondrial protein CHCHD2 in the Pathogenesis of Parkinson’s Disease<\/p>\n

Within our cells, tiny structures called mitochondria act as the power plants to generate the energy those cells need to survive. Although researchers don\u2019t understand exactly why, they know that when the power plants malfunction, the disruption in the mitochondrial system can result in a range of different illnesses, including Parkinson\u2019s disease.<\/p>\n

At McGill University, geneticist Eric Shoubridge is studying the function of a tiny protein called CHCHD2, which lives in the space between mitochondria\u2019s outer and inner membranes.<\/p>\n

\u201cIt\u2019s a little mysterious, what this protein does,\u201d says Shoubridge, a professor in the Department of Human Genetics. \u201cThe reason we became interested is because it\u2019s a mitochondrial protein that has been associated with Parkinson\u2019s disease.\u201d<\/p>\n

Shoubridge believes mutated forms of the protein can be a rare cause of Parkinson\u2019s disease in some individuals. Carrying the mutation can also increase the risk of developing Parkinson\u2019s in some families. He hopes by studying the protein and its relationship to other genetic causes of Parkinson\u2019s disease, he will better understand CHCHD2\u2019s role. He also wants to know why, if the same biochemical system within a cell is disturbed, so many different types of disease result.<\/p>\n

Epilepsy, heart disease, diabetes, blindness, deafness, and several kinds of neurodegenerative diseases like Parkinson\u2019s are all associated with mutations in different kinds of mitochondrial genes.<\/p>\n

Already, Shoubridge has learned that CHCHD2 is part of a protein complex that is associated with frontal temporal dementia and Amyotrophic Lateral Sclerosis \u2013 ALS.<\/p>\n

\u201cMaybe this complex has some fundamental role in maintaining mitochondrial function, and when it goes wrong, it can cause different types of neurodegenerative disorders,\u201d he says.<\/p>\n

By figuring out the normal function of this protein within mitochondria, Shoubridge hopes the discovery will eventually lead to knowledge about what makes the dopamine-producing brain cells that are responsible for movement susceptible to Parkinson\u2019s disease.<\/p>\n

If Shoubridge and his lab understand the normal function of all the proteins associated with Parkinson\u2019s disease, such as CHCHD2, they hope eventually to provide a target for a drug or find a way to undo the process that results in the disease.<\/p>\n

For Shoubridge, the research he conducts strikes close to home. His family is affected by Huntington\u2019s disease, another progressive brain disorder. Huntington\u2019s has also been linked to disruptions in the mitochondrial system within cells \u2013 so unlocking his puzzle and learning the role of CHCHD2 is particularly meaningful.<\/p>\n

\u201cIt might allow us to mitigate the effects of the mutation in these particular cells,\u201d he says.\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Eric Shoubridge, professeur Université McGill Subventions pour projets pilotes 45 000 $ sur 1 an Disponible seulement en Anglais Role of … En savoir plus<\/a><\/p>\n","protected":false},"author":90,"featured_media":0,"parent":7074,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-layout-content-sidebar.php","meta":[],"categories":[],"yoast_head":"\nComprendre le r\u00f4le que joue une toute petite prot\u00e9ine dans l\u2019apparition de la maladie de Parkinson - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprendre le r\u00f4le que joue une toute petite prot\u00e9ine dans l\u2019apparition de la maladie de Parkinson - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Eric Shoubridge, professeur Université McGill Subventions pour projets pilotes 45 000 $ sur 1 an Disponible seulement en Anglais Role of ... 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