{"id":7388,"date":"2017-12-07T15:34:31","date_gmt":"2017-12-07T15:34:31","guid":{"rendered":"http:\/\/www.parkinson.ca\/research-fr\/2013-2015-projets-de-recherche\/exploration-des-differents-visages-dune-proteine-au-coeur-de-la-maladie-de-parkinson\/"},"modified":"2017-12-07T15:34:31","modified_gmt":"2017-12-07T15:34:31","slug":"exploration-des-differents-visages-dune-proteine-au-coeur-de-la-maladie-de-parkinson","status":"publish","type":"page","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/recherche\/2013-2015-projets-de-recherche\/exploration-des-differents-visages-dune-proteine-au-coeur-de-la-maladie-de-parkinson\/","title":{"rendered":"Exploration des diff\u00e9rents visages d\u2019une prot\u00e9ine au c\u0153ur de la maladie de Parkinson"},"content":{"rendered":"
\"\"Martin Duennwald<\/strong>, Professeur adjoint,
\nD\u00e9partement de biologie, Universit\u00e9 Western
\nBourse de projet pilote – 45 000 $
\nfinanc\u00e9e par le Fonds qu\u00e9b\u00e9cois de recherche sur le Parkinson*<\/p>\n

Identification des substrats de la parkine dans la maladie de Parkinson pr\u00e9coce<\/strong><\/p>\n

Dans sa jeunesse, en Allemagne, Martin Duennwald se passionne pour la g\u00e9n\u00e9tique quand il s\u2019initie \u00e0 cette mati\u00e8re \u00e0 l\u2019\u00e9cole secondaire. Il se rappelle \u00e9galement un professeur atteint de Parkinson pr\u00e9coce, qui se d\u00e9t\u00e9riorait rapidement. \u00ab Une trag\u00e9die \u00bb, se souvient-il.<\/p>\n

Sa carri\u00e8re actuelle refl\u00e8te ces deux moments de vie marquants. Le biologiste, professeur au D\u00e9partement de pathologie de l’Universit\u00e9 Western, explore en profondeur les facteurs g\u00e9n\u00e9tiques responsables de la maladie de Parkinson. Il s\u2019int\u00e9resse plus particuli\u00e8rement au comportement du g\u00e8ne r\u00e9gissant une prot\u00e9ine cl\u00e9 appel\u00e9e \u00ab parkine \u00bb, qui semble impliqu\u00e9e dans la d\u00e9gradation d\u2019autres prot\u00e9ines. La d\u00e9faillance de la parkine entra\u00eene la cascade de sympt\u00f4mes associ\u00e9s \u00e0 la maladie.<\/p>\n

Des recherches r\u00e9centes r\u00e9v\u00e8lent qu\u2019un m\u00e9canisme assure habituellement la r\u00e9gulation de la parkine pour emp\u00eacher ce type de d\u00e9gradation anormale. Duennwald et ses coll\u00e8gues utilisent des formes mut\u00e9es de la prot\u00e9ine pour tenter de mieux comprendre la nature de ces m\u00e9canismes biochimiques.<\/p>\n

\u00ab Ces mutations nous indiquent quelle mol\u00e9cule cibler, il reste [cependant] \u00e0 comprendre son r\u00f4le exact et comment la d\u00e9faillance de la parkine intervient dans la maladie de Parkinson \u00bb, explique t-il.<\/p>\n

Duennwald esp\u00e8re d\u00e9couvrir quels changements surviennent dans les formes saines typiques de la parkine pour provoquer la maladie. Cette piste pourrait \u00e9ventuellement mener \u00e0 des mesures correctives en vue d\u2019emp\u00eacher ou de renverser ces changements, mais il pr\u00e9cise que beaucoup reste encore \u00e0 faire pour formuler une strat\u00e9gie th\u00e9rapeutique.<\/p>\n

En attendant, il est reconnaissant du soutien re\u00e7u de la Soci\u00e9t\u00e9 Parkinson, qui lui permet de situer ce probl\u00e8me dans une perspective nouvelle. Il ajoute que la recherche s\u2019amorce et qu\u2019il dispose encore de peu de donn\u00e9es \u00e0 \u00e9valuer, un crit\u00e8re important pour la plupart des bailleurs de fonds. \u00ab Ce n\u2019est qu\u2019une question de temps, insiste Duennwald, mais cette \u00e9tape est n\u00e9cessaire. \u00bb<\/p>\n

\u00ab Cette d\u00e9marche exige beaucoup de temps et d\u2019argent, conclut-il, voil\u00e0 pourquoi nous appr\u00e9cions cette aide financi\u00e8re \u00e0 sa juste valeur. \u00bb<\/p>\n

* Le Fonds de recherche du Qu\u00e9bec sur la maladie de Parkinson est financ\u00e9 notamment par le Fonds de recherche Saucier\u2011van Berkom-Soci\u00e9t\u00e9 Parkinson du Qu\u00e9bec et la Soci\u00e9t\u00e9 Parkinson de la Saskatchewan.\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Martin Duennwald, Professeur adjoint, D\u00e9partement de biologie, Universit\u00e9 Western Bourse de projet pilote – 45 000 $ financ\u00e9e par le … En savoir plus<\/a><\/p>\n","protected":false},"author":67,"featured_media":0,"parent":7027,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"categories":[],"yoast_head":"\nExploration des diff\u00e9rents visages d\u2019une prot\u00e9ine au c\u0153ur de la maladie de Parkinson - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploration des diff\u00e9rents visages d\u2019une prot\u00e9ine au c\u0153ur de la maladie de Parkinson - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Martin Duennwald, Professeur adjoint, D\u00e9partement de biologie, Universit\u00e9 Western Bourse de projet pilote – 45 000 $ financ\u00e9e par le ... 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