{"id":1155,"date":"2017-02-13T12:04:18","date_gmt":"2017-02-13T17:04:18","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1155"},"modified":"2017-02-13T12:04:18","modified_gmt":"2017-02-13T17:04:18","slug":"the-value-of-basic-research-discovering-links-to-parkinsons-2","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/","title":{"rendered":"The value of basic research: Discovering links to Parkinson’s"},"content":{"rendered":"
\"Geoffrey

Geoffrey Hesketh, Cell biologist<\/p><\/div>\n

The beauty of basic research is that sometimes, when you’re not looking for it, you make a discovery that answers a critical question in an entirely new or different field.<\/p>\n

That’s what happened to Geoffrey Hesketh. Hesketh, a cell biologist, was investigating how proteins move around in cells to arrive at their surface in the correct order required to do their jobs.\u00a0 He was concentrating on the Retromer proteins, a group of proteins that work together to pick transport proteins from their starting point to the correct spots that allow them to send and receive communications signals.<\/p>\n

Other researchers had already figured out that damaged forms of one particular protein in the group \u2013 a protein called VPS35 \u2013 lead to Parkinson’s disease. Hesketh’s work revealed that nine other genes associated with Parkinson’s disease are also part of the Retromer group. That discovery points to this group of proteins as being critical players in the cause of Parkinson’s disease.<\/p>\n

One theory is that any defect in the Retromer pathway results in fewer proteins getting to the right spots on the surface of brain cells. That could disrupt communication among the cells. Cells that produce dopamine \u2013 the chemical in the brain that affects movement \u2013 could be more susceptible to this disruption.<\/p>\n

\u00ab\u00a0Or it just could be that after losing their connections with the neighbouring cells, these cells (with damaged Retromer proteins) just shrivel up and die,\u00a0\u00bb Hesketh says.
\nKnowing exactly what goes wrong at the cellular level is critical for the design of any future drug to treat Parkinson’s, says Hesketh.<\/p>\n

Now Hesketh, who has switched the focus of his project to Parkinson’s, uses a technique called mass spectrometry to screen all the proteins in the Retromer group. He wants to identify all the proteins they communicate with, because they could also be implicated in Parkinson’s disease. (Genes make proteins to perform functions.)<\/p>\n

Hesketh is now more than halfway through a two-year, $100,000 Basic Research Fellowship from the Parkinson Canada Research Program to pursue this research at the Lunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital in Toronto.<\/p>\n

At this point, he’s most excited about the discovery of molecular insights into the \u00ab\u00a0membrane targeting\u00a0\u00bb or clumping of alpha-Synuclein (a-Syn), a gene at the very centre of Parkinson’s disease, and long suspected in the formation of Lewy bodies.<\/p>\n

\u00ab\u00a0Knowledge of the precise mechanism of a-Syn membrane binding would be of significant value to the Parkinson’s research community and has the potential to lead to new treatments,\u00a0\u00bb says Hesketh.<\/p>\n

Another aim of his work is to complete a \u00ab\u00a0BioID,\u00a0\u00bb and mass spectrometry, of all of the genes known to be associated with Parkinson’s disease, about 50 in total \u2013 so far. He is collaborating with Drs. Ted Fon and Heidi McBride of the Montreal Neurological Institute at McGill University, who also have relationships with Parkinson Canada. (Dr. Fon is a previous Chair of our Scientific Advisory Board.)\u00a0 He is also investigating with them on how the various genes and their proteins impact the quality of a cell’s mitochondria, its energy source.<\/p>\n

Hesketh is passionate about the need for basic research and its unintended consequences. \u00ab\u00a0Parkinson’s found me, rather than the other way around,\u00a0\u00bb he says. \u00ab\u00a0I was looking into a pathway that I was pursuing out of curiosity. After a couple of years, we stumbled upon this connection to Parkinson’s disease that probably never would have been found, if we hadn’t gone down this curiosity-driven path. The discovery provided a new framework to my research.\u00a0\u00bb<\/p>\n

He’s a good example of how basic science research expands our knowledge base and can lead to potential new avenues of exploration and possible clinical applications.<\/p>\n

\u00ab\u00a0My research aims to characterize the interactions made by Parkinson’s-associated genes with the goal of identifying cell pathways and functions central to the development and progression of Parkinson’s disease. This investigation offers great promise in discovering the fundamental cause of Parkinson’s, and I believe, offers our best shot at ultimately finding a cure.\u00a0\u00bb<\/p>\n

You can watch our previously recorded interview with Hesketh<\/a>.\u00a0 You can also read about other researchers<\/a> funded by the Parkinson Canada Research Program on our website at archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

The beauty of basic research is that sometimes, when you’re not looking for it, you make a discovery that answers … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nThe value of basic research: Discovering links to Parkinson's - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The value of basic research: Discovering links to Parkinson's - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"The beauty of basic research is that sometimes, when you’re not looking for it, you make a discovery that answers ... En savoir plus\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Parkinson Canada\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/parkinsoncanada\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-02-13T17:04:18+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/parkinsonpost.com\/wp-content\/uploads\/2017-02-13-01-hesketh.jpg\" \/>\n<meta name=\"author\" content=\"communications@parkinson.ca\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:site\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"communications@parkinson.ca\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/\",\"name\":\"The value of basic research: Discovering links to Parkinson's - Parkinson Canada\",\"isPartOf\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\"},\"datePublished\":\"2017-02-13T17:04:18+00:00\",\"dateModified\":\"2017-02-13T17:04:18+00:00\",\"author\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\"},\"breadcrumb\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The value of basic research: Discovering links to Parkinson’s\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/\",\"name\":\"Parkinson Canada\",\"description\":\"Empowering the Parkinson's community across Canada\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\",\"name\":\"communications@parkinson.ca\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"caption\":\"communications@parkinson.ca\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The value of basic research: Discovering links to Parkinson's - Parkinson Canada","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"The value of basic research: Discovering links to Parkinson's - Parkinson Canada","og_description":"The beauty of basic research is that sometimes, when you’re not looking for it, you make a discovery that answers ... En savoir plus","og_url":"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/","og_site_name":"Parkinson Canada","article_publisher":"https:\/\/www.facebook.com\/parkinsoncanada\/","article_published_time":"2017-02-13T17:04:18+00:00","og_image":[{"url":"http:\/\/parkinsonpost.com\/wp-content\/uploads\/2017-02-13-01-hesketh.jpg"}],"author":"communications@parkinson.ca","twitter_card":"summary_large_image","twitter_creator":"@ParkinsonCanada","twitter_site":"@ParkinsonCanada","twitter_misc":{"\u00c9crit par":"communications@parkinson.ca","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/","url":"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/","name":"The value of basic research: Discovering links to Parkinson's - Parkinson Canada","isPartOf":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#website"},"datePublished":"2017-02-13T17:04:18+00:00","dateModified":"2017-02-13T17:04:18+00:00","author":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9"},"breadcrumb":{"@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/the-value-of-basic-research-discovering-links-to-parkinsons-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/archiveparkinson.thedev.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"The value of basic research: Discovering links to Parkinson’s"}]},{"@type":"WebSite","@id":"https:\/\/archiveparkinson.thedev.ca\/#website","url":"https:\/\/archiveparkinson.thedev.ca\/","name":"Parkinson Canada","description":"Empowering the Parkinson's community across Canada","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9","name":"communications@parkinson.ca","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","caption":"communications@parkinson.ca"}}]}},"_links":{"self":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/1155"}],"collection":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/comments?post=1155"}],"version-history":[{"count":0,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/1155\/revisions"}],"wp:attachment":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/media?parent=1155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/categories?post=1155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/tags?post=1155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}