{"id":1290,"date":"2017-06-20T12:02:26","date_gmt":"2017-06-20T16:02:26","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1290"},"modified":"2017-06-20T12:02:26","modified_gmt":"2017-06-20T16:02:26","slug":"chasing-the-culprit-in-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/chasing-the-culprit-in-parkinsons-disease\/","title":{"rendered":"Chasing the culprit in Parkinson\u2019s disease"},"content":{"rendered":"
\"Joel

Joel Watts<\/p><\/div>\n

When Joel Watts<\/a> was 10 years old, his father died of Creutzfeldt-Jakob Disease (CJD), a rare brain disorder caused by the strange behaviour of a class of proteins called prions. These agents later became notorious as the cause of the now infamous brain-wasting condition dubbed \u201cmad cow disease.\u201d<\/p>\n

But Watts, whose father died in the early 1990s, did not connect his father\u2019s loss to any specific neurodegenerative disorder until much later, when he was studying at university. Today, the biochemistry professor at the University of Toronto is on the cutting edge of investigating the similarities between prions and the way other proteins spread through the brain and compromise its functions.<\/p>\n

\u201cWhat I\u2019m trying to do is take something that is known about prion disease and apply it to Parkinson\u2019s research,\u201d Watts says. This research is being funded by a two-year, $90,000, Pedaling for Parkinson\u2019s New Investigator Award from the Parkinson Canada Research Program.<\/a><\/p>\n

Instead of prions, he studies a protein called \u03b1-synuclein, which is directly involved in the development of Parkinson\u2019s. The comparison with prions lies in the way accumulations or clumps of \u03b1-synuclein spread throughout the brain.<\/p>\n

\u201cThis aggregate might start in one cell and then somehow get out of that cell and make its way into a neighbouring cell,\u201d says Watts. \u201cThese little pieces of aggregated protein can then start the process in the next cell.\u201d<\/p>\n

Just as the mis-folded arrangement of prions damages brain cells, so too does the shape of \u03b1-synuclein affect brain cells and contribute to Parkinson\u2019s disease. Watts is categorizing these various shapes and their role in the development of this disorder. His ultimate goal is to shed light on mechanisms that a new therapy could target.<\/p>\n

Watts emphasizes that the infectious diseases prions cause, such as CJD, are entirely distinct from brain disorders like Alzheimer\u2019s or Parkinson\u2019s, which have never been identified as contagious or communicable. Nevertheless, Watts remains eager to build on the body of knowledge that surrounds prions, which he believes will lead to fresh insights about Parkinson\u2019s.<\/p>\n

\u201cWith prions, the protein exists on the outside of the cell so it\u2019s very easy for it to touch another cell,\u201d he says. \u201cWhereas \u03b1-synuclein is inside the cell, so how does it get out of one cell and get into another cell? That\u2019s one of the hottest areas of research right now.\u201d<\/p>\n

This spring, Watts presented an update on his research to the Parkinson community in Parry Sound, Ontario, where the Pedaling for Parkinson\u2019s event is held each summer. Previous Parkinson Canada funded researchers will ride alongside other riders on July 14 to 16, as part of the seventh annual Pedaling for Parkinson\u2019s event. Join them at pedalingforparkinsons.ca<\/a>.<\/p>\n

Read about other researchers<\/a> recently funded by the Parkinson Canada Research Program by visiting the research section of archiveparkinson.thedev.ca.<\/p>\n","protected":false},"excerpt":{"rendered":"

When Joel Watts was 10 years old, his father died of Creutzfeldt-Jakob Disease (CJD), a rare brain disorder caused by … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nChasing the culprit in Parkinson\u2019s disease - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chasing the culprit in Parkinson\u2019s disease - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"When Joel Watts was 10 years old, his father died of Creutzfeldt-Jakob Disease (CJD), a rare brain disorder caused by ... 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