{"id":1359,"date":"2017-10-17T00:03:19","date_gmt":"2017-10-17T04:03:19","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1359"},"modified":"2017-10-17T00:03:19","modified_gmt":"2017-10-17T04:03:19","slug":"understanding-how-parkinsons-spreads-through-the-brain","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-how-parkinsons-spreads-through-the-brain\/","title":{"rendered":"Understanding how Parkinson\u2019s spreads through the brain"},"content":{"rendered":"
\"\"

Abid Oueslati, Assistant Professor<\/p><\/div>\n

Abid Oueslati\u2019s fascination with the brain began as part of his initial experiences with scientific research in France. Later, while pursuing post-doctoral studies in Switzerland, he began to tackle Parkinson\u2019s disease as a bio-molecular puzzle whose solution could improve the lives of patients around the world.<\/p>\n

One molecule in particular captured his imagination: the intricate protein known as \u03b1-synuclein, which can spread through the brains of Parkinson\u2019s disease patients as the ailment develops. For Oueslati, who is now an assistant professor in molecular medicine at Laval University, this behaviour closely resembles that of another problematic protein, the notorious prion.<\/p>\n

Scientists first identified prions about 20 years ago in the search for the causes of mysterious plaques that formed in the brain and broke down its network of connections, leaving an affected person or animal increasingly disabled. The culprit turned out to be these strange proteins whose molecular structures are folded in awkward patterns and move between brain cells to disrupt healthy tissue. Oueslati has seen a similar pattern to the way \u03b1-synuclein affects the brain.<\/p>\n

\u201cIt makes plain the progress of the disease,\u201d he says. \u201cIt\u2019s opening up a new area of research into Parkinson\u2019s disease because it shows a new mechanism. It also offers new opportunities for new therapies \u2014 stopping or at least reducing the disease progress.\u201d<\/p>\n

Parkinson Canada is supporting Oueslati\u2019s work, which he regards as the initial building block that will help him establish an ongoing research program in this field. He received a two-year, $90,000, Pedaling for Parkinson\u2019s New Investigator Award, from the Parkinson Canada Research Program.<\/p>\n

\u201cThis is a tremendous help to jump-start this project,\u201d he explains. \u201cWe\u2019ll be able to collect data and publish the first conception of what we want to do.\u201d<\/p>\n

Among the most significant developments he anticipates will be a far more effective laboratory procedure for studying Parkinson\u2019s disease in mice. Researchers currently try to mimic the condition by adding excessive amounts of \u03b1-synuclein into the brains of these animals, but the technique yields haphazard results. By applying a model of prion-like propagation, however, Oueslati has been able to use viruses to deliver the protein into the brain in a way that more closely resembles the advance of Parkinson\u2019s.<\/p>\n

\u201cThe problem today is one of reproducibility,\u201d he explains. \u201cOur purpose is to develop an accurate, simple, and controllable model.\u201d<\/p>\n

He is also taking stem cell samples from Parkinson\u2019s patients and growing them in culture to learn more about genetic features that might be responsible for the condition in the first place.<\/p>\n

\u201cThis is a new field,\u201d Oueslati notes, \u201cwhich could show the vulnerability of these cells to some kind of external event that leads to Parkinson\u2019s.\u201d<\/p>\n

Read about other researchers<\/a> recently funded by the Parkinson Canada Research Program by visiting the research section of archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Abid Oueslati\u2019s fascination with the brain began as part of his initial experiences with scientific research in France. Later, while … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nUnderstanding how Parkinson\u2019s spreads through the brain - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding how Parkinson\u2019s spreads through the brain - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Abid Oueslati\u2019s fascination with the brain began as part of his initial experiences with scientific research in France. Later, while ... 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