{"id":1395,"date":"2017-12-13T00:02:41","date_gmt":"2017-12-13T05:02:41","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1395"},"modified":"2017-12-13T00:02:41","modified_gmt":"2017-12-13T05:02:41","slug":"new-hope-to-halt-compulsive-gambling","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/new-hope-to-halt-compulsive-gambling\/","title":{"rendered":"New hope to halt compulsive gambling"},"content":{"rendered":"
\"\"

Dr. Catharine Winstanley<\/p><\/div>\n

For people with Parkinson\u2019s disease, it\u2019s usually a tremendous relief to find a drug to treat the tremors, stiffness or the freezing that causes some of them to halt in place.<\/p>\n

But for a significant minority of people \u2013 up to 20 per cent \u2013 the class of drugs that is often most effective in controlling these motor symptoms comes with a devastating side effect. These synthetic dopamine drugs, called dopamine agonists, can introduce risky behaviour, including compulsive gambling that may cause people to drain their life-savings or ruin their relationships.<\/p>\n

At the University of British Columbia, behavioural neuroscientist Catharine Winstanley uses animal models to investigate the link between a protein called GSK3beta, and the impulse control problems some people develop when taking these drugs.<\/p>\n

The risky behaviours often make both doctors and people with Parkinson\u2019s reluctant to start the synthetic dopamine drugs.<\/p>\n

Although GSK3beta is associated with several psychiatric disorders, so far researchers don\u2019t know its precise role in causing them. \u00a0What they do know is that certain other drugs, including lithium and new \u00a0lithium derivatives, seem to block GSK3beta, preventing the development of impulse control problems.<\/p>\n

Winstanley and her colleagues are testing these drugs, which have already been demonstrated to be safe. They\u2019re hoping that giving one of these drugs to people already taking dopamine agonists will prevent them from developing these impulsive behaviours. Winstanley received a $45,000 pilot project grant funded by Parkinson Society British Columbia from the Parkinson Canada Research Program for this project.<\/p>\n

If Winstanley is successful, \u201cit would make the experience of being treated with these compounds (dopamine agonists) a lot safer and less worrying for the patients,\u201d she says.<\/p>\n

People with Parkinson\u2019s could take both the synthetic dopamine agonists and the additional medication, relieving their motor symptoms without jeopardizing their supportive relationships and livelihood.<\/p>\n

Currently, the impulse control issues are \u201cthe worst outcome for someone who is trying to develop a new medical treatment,\u201d says Winstanley, an associate professor at UBC. \u201cThe drug they\u2019ve developed turns out to cause something worse than the disease they were trying to treat.\u201d<\/p>\n

The heart-rending effects of compulsive gambling and other impulsive behaviours compelled Winstanley to tackle this research project, she says. She empathizes with people with Parkinson\u2019s, whose hopes are raised by the prospect of taking the dopamine agonist medication, only to have those hopes dashed when the risky behaviours emerge.<\/p>\n

\u201cYou don\u2019t have to look very far before you find a friend or a relative who is dealing with the fallout from Parkinson\u2019s disease,\u201d says Winstanley. \u201cI just want to do the little bit I can to make that better. This is the area where I think my own research can make a difference.\u201d<\/p>\n

Read about\u00a0other researchers\u00a0<\/a>recently funded by the Parkinson Canada Research Program by visiting the research section of\u00a0archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

For people with Parkinson\u2019s disease, it\u2019s usually a tremendous relief to find a drug to treat the tremors, stiffness or … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nNew hope to halt compulsive gambling - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New hope to halt compulsive gambling - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"For people with Parkinson\u2019s disease, it\u2019s usually a tremendous relief to find a drug to treat the tremors, stiffness or ... 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