{"id":1482,"date":"2018-02-20T23:32:53","date_gmt":"2018-02-21T04:32:53","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1482"},"modified":"2018-02-20T23:32:53","modified_gmt":"2018-02-21T04:32:53","slug":"improving-damage-detection-in-the-brain","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/","title":{"rendered":"Improving damage detection in the brain"},"content":{"rendered":"
\"\"

Professor Jean-Fran\u00e7ois Trempe<\/span><\/p><\/div>\n

A pair of proteins, whose malfunction is associated with Parkinson\u2019s disease, normally work together to fulfill valuable housekeeping chores within the body. They keep brain cells healthy, for example, by discarding dead or dying material inside them. But these proteins have to be tightly controlled, because if they \u201chelp\u201d too much, they can become harmful. When they aren\u2019t regulated, the damaged proteins end up killing the brain cells they were designed to save.<\/p>\n

\u201cIt\u2019s like having a bulldog on a leash,\u201d says Jean-Fran\u00e7ois Trempe, an assistant professor at McGill University\u2019s Department of Pharmacology and Therapeutics. \u201cYou have to keep it under control.\u201d<\/p>\n

A decade ago, Trempe began studying Parkin, one of the most powerful of these proteins.<\/p>\n

\u201cParkin is a protein that can destroy parts of the cell, so you don\u2019t want it to be active all of the time,\u201d Trempe says.\u00a0 \u201cYou only want it to get rid of the bad parts of cells.\u201d<\/p>\n

Parkin\u2019s activity is controlled by another protein, a gene called PINK1. PINK1 constantly enters the\u00a0 mitochondrion, an internal part of the cell that oversees the production of energy. When the mitochondrion is healthy, it simply eliminates PINK1. If it is malfunctioning, however, PINK1 builds up within brain cells, which serves as a signal to Parkin to move in and eliminate them.<\/p>\n

The disruption of mitochondrial function is a hallmark of Parkinson\u2019s disease, which has led Trempe to regard PINK1 as a key to understanding this process. Other cells in the body are also susceptible to mitochondrial damage, he says, but they manage to recover successfully. Those brain cells that do not recover appear to be under stress, and thus are more sensitive to the loss of PINK1.<\/p>\n

\u201cThis is what I find fascinating \u2014 why a mutation in a gene that you find everywhere only causes the loss of a subset of neurons,\u201d he says. \u201cThis is what we think is happening.\u201d<\/p>\n

There are very few genes like PINK1 in the body, which makes it all the more interesting to study. If specific compounds can be identified to stabilize PINK1 so bad mitochondria are more readily detected and removed by Parkin, the result could allow these cells to repair themselves, fending off the onset of Parkinson\u2019s disease.<\/p>\n

\u201cWe need to confirm this idea (of cell reparation), which is why we are conducting this proof-of-concept study,\u201d says Trempe. \u201cIt will be a tool that should lead us to some very effective strategies.\u201d<\/p>\n

Dr. Trempe\u2019s 2 year Pilot Project Grant is funded by Peter Cipriano through the Parkinson Canada Research Program.<\/p>\n

Read about other researchers<\/a> recently funded by visiting the research section of archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

A pair of proteins, whose malfunction is associated with Parkinson\u2019s disease, normally work together to fulfill valuable housekeeping chores within … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nImproving damage detection in the brain - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Improving damage detection in the brain - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"A pair of proteins, whose malfunction is associated with Parkinson\u2019s disease, normally work together to fulfill valuable housekeeping chores within ... En savoir plus\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/\" \/>\n<meta property=\"og:site_name\" content=\"Parkinson Canada\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/parkinsoncanada\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-21T04:32:53+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/parkinsonpost.com\/wp-content\/uploads\/Trempe_eppsize-262x300.jpg\" \/>\n<meta name=\"author\" content=\"communications@parkinson.ca\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:site\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"communications@parkinson.ca\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/\",\"name\":\"Improving damage detection in the brain - Parkinson Canada\",\"isPartOf\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\"},\"datePublished\":\"2018-02-21T04:32:53+00:00\",\"dateModified\":\"2018-02-21T04:32:53+00:00\",\"author\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\"},\"breadcrumb\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Improving damage detection in the brain\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/\",\"name\":\"Parkinson Canada\",\"description\":\"Empowering the Parkinson's community across Canada\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\",\"name\":\"communications@parkinson.ca\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"caption\":\"communications@parkinson.ca\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Improving damage detection in the brain - Parkinson Canada","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"Improving damage detection in the brain - Parkinson Canada","og_description":"A pair of proteins, whose malfunction is associated with Parkinson\u2019s disease, normally work together to fulfill valuable housekeeping chores within ... En savoir plus","og_url":"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/","og_site_name":"Parkinson Canada","article_publisher":"https:\/\/www.facebook.com\/parkinsoncanada\/","article_published_time":"2018-02-21T04:32:53+00:00","og_image":[{"url":"http:\/\/parkinsonpost.com\/wp-content\/uploads\/Trempe_eppsize-262x300.jpg"}],"author":"communications@parkinson.ca","twitter_card":"summary_large_image","twitter_creator":"@ParkinsonCanada","twitter_site":"@ParkinsonCanada","twitter_misc":{"\u00c9crit par":"communications@parkinson.ca","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/","url":"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/","name":"Improving damage detection in the brain - Parkinson Canada","isPartOf":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#website"},"datePublished":"2018-02-21T04:32:53+00:00","dateModified":"2018-02-21T04:32:53+00:00","author":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9"},"breadcrumb":{"@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/improving-damage-detection-in-the-brain\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/archiveparkinson.thedev.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Improving damage detection in the brain"}]},{"@type":"WebSite","@id":"https:\/\/archiveparkinson.thedev.ca\/#website","url":"https:\/\/archiveparkinson.thedev.ca\/","name":"Parkinson Canada","description":"Empowering the Parkinson's community across Canada","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9","name":"communications@parkinson.ca","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","caption":"communications@parkinson.ca"}}]}},"_links":{"self":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/1482"}],"collection":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/comments?post=1482"}],"version-history":[{"count":0,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/1482\/revisions"}],"wp:attachment":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/media?parent=1482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/categories?post=1482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/tags?post=1482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}