{"id":1765,"date":"2018-08-14T15:01:20","date_gmt":"2018-08-14T19:01:20","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1765"},"modified":"2018-08-14T15:01:20","modified_gmt":"2018-08-14T19:01:20","slug":"connecting-transplanted-brain-cells","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/connecting-transplanted-brain-cells\/","title":{"rendered":"Connecting Transplanted Brain Cells"},"content":{"rendered":"

Finding the right path: PlexinC1-negative dopaminergic neurons for personalized cell replacement therapy of Parkinson\u2019s disease<\/span><\/p>\n

\"image

Caroline Lafrechoux
Laval University<\/span><\/p><\/div>At Laval University, Master\u2019s student Caroline Lafrechoux is investigating how to guide the axons, or the connectors, between transplanted cells in the area of the brain where dopamine-producing cells are dying. If she can find a way to guide the axons to the right locations within the brain, she\u2019ll improve the prospects for brain cell transplantation as a way to replace the damaged and dying cells that are causing Parkinson\u2019s disease.<\/p>\n

Neuroscientist Caroline Lafrechoux has been fascinated with the networks of neurons and electrical signals in the brain since she was seven years old, and saw a young cousin suffer an epileptic seizure.<\/p>\n

When she learned that epilepsy is the result of electrical or signalling disturbances in the brain, the explanation sparked Lafrechoux\u2019s determination to find out more about this mysterious organ.<\/p>\n

Today, thanks to the two-year $30,000 Parkinson Canada Graduate Student Award funded by the Lanka Charitable Foundation, the Master\u2019s student at Laval University is channelling her early fascination with those neural networks into research on the connections between cells in the brains of people with Parkinson\u2019s disease.<\/p>\n

Using a mouse model, Lafrechoux is investigating how to guide axons, the long, thread-like portion of cells, into position so they can conduct signals from newly transplanted brain cells to other cells, directing movement.<\/p>\n

If Lafrechoux can figure out how to introduce a chemical cue that guides the axons where they need to go, she will have solved a crucial piece of the puzzle that has so far stymied researchers trying to use cell transplantation to treat Parkinson\u2019s.<\/p>\n

\u201cWhat I\u2019m hoping will happen is that once I inject these new neurons, I will restore normal motor locomotion,\u201d she says. \u201cI\u2019m hoping that the cells I inject will replace the ones that have been lost\u2014exactly.\u201d<\/p>\n

Eventually, if Lafrechoux can restore connections and neural pathways among mouse brain cells, she wants to engineer human brain cells that she can transplant into the mouse models.<\/p>\n

\u201cIf it works \u2026 it would give hope for cell replacement therapy,\u201d she says. \u201cIt\u2019s personalized medicine, because you can take a patient\u2019s own cells, transform them, and put them back into their brain, replacing the ones that have died.\u201d<\/p>\n

Although Lafrechoux enjoys the challenge that Parkinson\u2019s disease presents for researchers, she is motivated by the suffering the disease causes people who have it.<\/p>\n

\u201cWe absolutely need to find an answer,\u201d she says.<\/p>\n

Read about\u00a0other researchers<\/a>\u00a0recently funded by the Parkinson Canada Research Program by visiting the research section of\u00a0archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Finding the right path: PlexinC1-negative dopaminergic neurons for personalized cell replacement therapy of Parkinson\u2019s disease At Laval University, Master\u2019s student … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":1767,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nConnecting Transplanted Brain Cells - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Connecting Transplanted Brain Cells - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Finding the right path: PlexinC1-negative dopaminergic neurons for personalized cell replacement therapy of Parkinson\u2019s disease At Laval University, Master\u2019s student ... 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