{"id":1850,"date":"2018-10-16T09:01:05","date_gmt":"2018-10-16T13:01:05","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1850"},"modified":"2018-10-16T09:01:05","modified_gmt":"2018-10-16T13:01:05","slug":"understanding-where-to-hit-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/","title":{"rendered":"Understanding where to hit Parkinson\u2019s disease"},"content":{"rendered":"
\"image

Ying Wang
Postdoctoral Fellow
McGill University <\/span><\/p><\/div>\n

Novel, tissue-specific, inducible, adult-onset reversible animal models for the role of mitochondria in Parkinson\u2019s disease<\/h3>\n

Using specially designed, genetically altered mice, McGill University postdoctoral researcher Ying Wang is demonstrating what type of age-dependent decline of nerve cell function could cause Parkinson\u2019s disease. By inducing Parkinson\u2019s and then using a drug to reverse the disease in her mouse model, she hopes to uncover whether and to what extent the damaged nerve cells can regain lost function and recover.<\/p>\n

Among the busiest parts of any cell is the mitochondrion, a structure that supplies energy, transmits signals, and even coordinates a programmed death sequence for cells when they come to the end of their useful life.<\/p>\n

Mitochondria function declines with age. Many researchers believe this problem may be the starting point\u2014and perhaps the main problem\u2014of the disorder.<\/p>\n

\u201cIf you want to help treat or cure a disease, you have to first understand why that disease behaves the way it does,\u201d says Ying Wang, a McGill University postdoctoral fellow. \u201cMy project is aimed at answering two important questions: is mitochondrial dysfunction the cause of this disease, and if we can find a way to restore that function, would it reverse the course of the disease?\u201d<\/p>\n

With that goal in mind, Wang has attempted to better model the way mitochondria is disrupted in Parkinson\u2019s, in order to prove or disprove the causal role of mitochondria. She\u2019s working with mice that have been genetically modified to create chronic stress on mitochondria, specifically in a particularly hard-working class of brain cells that are susceptible to this disease. Furthermore, she\u2019s already discovered that a drug she gives to those mice in water can reverse the problem with the mitochondria.<\/p>\n

\u201cIt\u2019s a simple, elegant model,\u201d says Wang. \u201cIt is unique because it induces adult-onset chronic loss of mitochondrial function. Furthermore, it is the first that allows us to turn the functional capacity of mitochondria off, and then back on again.\u201d Demonstrating that this drug can reverse damage to mitochondria in these mice means focusing on mitochondria is a good potential avenue for drug discovery.<\/p>\n

The lab of Dr. Siegfried Hekimi, where Wang earned her PhD in 2014, has been an ideal setting to carry out this work, she says.<\/p>\n

\u201cThis lab has been working on aging and these kinds of age-dependent diseases for the last 20 years,\u201d she says. \u201cWe have also been thinking of ways to improve mitochondrial function that could potentially benefit many age-related illnesses.\u201d<\/p>\n

Read about\u00a0other researchers<\/a>\u00a0recently funded by the Parkinson Canada Research Program by visiting the research section of\u00a0archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Novel, tissue-specific, inducible, adult-onset reversible animal models for the role of mitochondria in Parkinson\u2019s disease Using specially designed, genetically altered … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":1851,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nUnderstanding where to hit Parkinson\u2019s disease - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding where to hit Parkinson\u2019s disease - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Novel, tissue-specific, inducible, adult-onset reversible animal models for the role of mitochondria in Parkinson\u2019s disease Using specially designed, genetically altered ... En savoir plus\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Parkinson Canada\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/parkinsoncanada\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-10-16T13:01:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/03_Ying_Wang_300w.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"294\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"communications@parkinson.ca\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:site\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"communications@parkinson.ca\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/\",\"name\":\"Understanding where to hit Parkinson\u2019s disease - Parkinson Canada\",\"isPartOf\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\"},\"datePublished\":\"2018-10-16T13:01:05+00:00\",\"dateModified\":\"2018-10-16T13:01:05+00:00\",\"author\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\"},\"breadcrumb\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Understanding where to hit Parkinson\u2019s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/\",\"name\":\"Parkinson Canada\",\"description\":\"Empowering the Parkinson's community across Canada\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\",\"name\":\"communications@parkinson.ca\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"caption\":\"communications@parkinson.ca\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Understanding where to hit Parkinson\u2019s disease - Parkinson Canada","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"Understanding where to hit Parkinson\u2019s disease - Parkinson Canada","og_description":"Novel, tissue-specific, inducible, adult-onset reversible animal models for the role of mitochondria in Parkinson\u2019s disease Using specially designed, genetically altered ... En savoir plus","og_url":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/","og_site_name":"Parkinson Canada","article_publisher":"https:\/\/www.facebook.com\/parkinsoncanada\/","article_published_time":"2018-10-16T13:01:05+00:00","og_image":[{"width":300,"height":294,"url":"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/03_Ying_Wang_300w.jpg","type":"image\/jpeg"}],"author":"communications@parkinson.ca","twitter_card":"summary_large_image","twitter_creator":"@ParkinsonCanada","twitter_site":"@ParkinsonCanada","twitter_misc":{"\u00c9crit par":"communications@parkinson.ca","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/","url":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/","name":"Understanding where to hit Parkinson\u2019s disease - Parkinson Canada","isPartOf":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#website"},"datePublished":"2018-10-16T13:01:05+00:00","dateModified":"2018-10-16T13:01:05+00:00","author":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9"},"breadcrumb":{"@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/understanding-where-to-hit-parkinsons-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/archiveparkinson.thedev.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Understanding where to hit Parkinson\u2019s disease"}]},{"@type":"WebSite","@id":"https:\/\/archiveparkinson.thedev.ca\/#website","url":"https:\/\/archiveparkinson.thedev.ca\/","name":"Parkinson Canada","description":"Empowering the Parkinson's community across Canada","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9","name":"communications@parkinson.ca","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","caption":"communications@parkinson.ca"}}]}},"_links":{"self":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/1850"}],"collection":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/comments?post=1850"}],"version-history":[{"count":0,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/1850\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/media\/1851"}],"wp:attachment":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/media?parent=1850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/categories?post=1850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/tags?post=1850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}