{"id":1922,"date":"2018-11-20T16:24:05","date_gmt":"2018-11-20T21:24:05","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1922"},"modified":"2018-11-20T16:24:05","modified_gmt":"2018-11-20T21:24:05","slug":"preventing-a-cure-from-becoming-as-bad-as-the-disease","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/preventing-a-cure-from-becoming-as-bad-as-the-disease\/","title":{"rendered":"Preventing a cure from becoming as bad as the disease"},"content":{"rendered":"
\"\"

Dr. Martin Parent
Associate Professor, Laval University<\/span><\/p><\/div>\n

Dr.\u00a0Martin Parent, an associate professor at Laval University\u2019s Department of Psychiatry and Neuroscience, is studying the cause of dyskinesia, uncontrolled movements that are a side effect of the levodopa therapy that is still the best drug treatment for Parkinson\u2019s disease. He and his colleagues will be using an innovative new gene-editing technology to manipulate the function of a specific gene they regard as a primary cause of this problem.<\/strong><\/p>\n

The drug levodopa, or L-Dopa, remains the most effective and widely prescribed treatment for the symptoms of Parkinson\u2019s disease, but its side effects include involuntary movements called dyskinesia that can be more debilitating than the underlying disease.<\/p>\n

Dr.\u00a0Martin Parent is examining the causes of this unwanted interaction with an otherwise valuable drug.<\/p>\n

\u201cWe estimate that maybe 70 percent of patients will have dyskinesia after five or six years of treatment,\u201d he says. \u201cThat\u2019s a big problem.\u201d<\/p>\n

The heart of this problem appears to be the brain\u2019s response to Parkinson\u2019s, which reduces the number of healthy axons, the long, thread-like part of nerve cells in the brain that control movement. As axons disappear, they are steadily replaced by cells that do not function in the same way. These new cells are responsible for distorting the effectiveness of a key medication.<\/p>\n

\u201cThey take the L-dopa and then release dopamine in an uncontrolled way,\u201d says Parent. These bursts of dopamine flooding into the brain are reflected in the similarly uncontrolled movements associated with dyskinesia.<\/p>\n

Parent and his colleagues have traced this behaviour to a particular gene called VGluT3, which he pronounces, \u201cVee Glute\u00a0Three.\u201d Now, they\u2019re examining mice that have been genetically altered to prevent this gene from functioning, to see if that prevents dyskinesia from occurring in the presence of levodopa.<\/p>\n

Parent is also excited about using cutting-edge gene-editing technology, called CRISPR-Cas9, to \u201cknock out\u201d or remove this gene. This innovative approach, which has only been developed in the last couple of years, uses a virus to knock out VGluT3 in adult mice, something that was not previously possible. The technology results in a less cumbersome, more cost-effective process, so Parent expects this approach to accelerate the research.<\/p>\n

Above all, Parent hopes his findings ultimately help researchers and clinicians understand and overcome the challenge of using levodopa to benefit people with Parkinson\u2019s.<\/p>\n

\u201cThere are drugs that limit dyskinesia by decreasing the effect of L-Dopa, but that doesn\u2019t leave a patient any better off,\u201d he says. \u201cBy acting directly on the target gene, VGluT3, we hope we\u2019re going to have more success in clinical trials.\u201d<\/p>\n

Read about\u00a0other researchers<\/a>\u00a0recently funded by the Parkinson Canada Research Program by visiting the research section of\u00a0archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dr.\u00a0Martin Parent, an associate professor at Laval University\u2019s Department of Psychiatry and Neuroscience, is studying the cause of dyskinesia, uncontrolled … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":1928,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nPreventing a cure from becoming as bad as the disease - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preventing a cure from becoming as bad as the disease - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Dr.\u00a0Martin Parent, an associate professor at Laval University\u2019s Department of Psychiatry and Neuroscience, is studying the cause of dyskinesia, uncontrolled ... 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