{"id":2149,"date":"2019-02-19T15:49:05","date_gmt":"2019-02-19T20:49:05","guid":{"rendered":"https:\/\/parkinsonpost.com\/?p=2149"},"modified":"2019-02-19T15:49:05","modified_gmt":"2019-02-19T20:49:05","slug":"unmasking-molecular-culprits-in-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/unmasking-molecular-culprits-in-parkinsons-disease\/","title":{"rendered":"Unmasking molecular culprits in Parkinson\u2019s disease"},"content":{"rendered":"
\"\"

Mohamed Eldeeb McGill University<\/span><\/p><\/div>\n

Mohamed Eldeeb, a researcher at McGill University, is looking for molecules that regulate a crucial gene linked to the onset of Parkinson\u2019s disease. Using the advanced genome editing approach known as CRISPR, he intends to identify the particular agents that allow cells in the brain to become compromised, so that they no longer produce the dopamine necessary to control the body\u2019s muscle movements. In this way, he hopes to reveal which molecules might make the best targets for therapy to prevent this loss of function.<\/p>\n

Mohamed Eldeeb\u2019s curiosity about the behaviour of cancer cells led him to seek similar insights into the way brain cells respond to Parkinson\u2019s disease. As a doctoral student at the University of Alberta, he was intrigued by how cancer cells mounted a resistance to chemotherapy and began to explore the mechanisms that enabled these cells to fend off these powerful drugs. Now at McGill University as a postdoctoral researcher, he is exploring why brain cells find themselves unable to resist the process of neurodegeneration, thanks to a Basic Research Fellowship of $100,000 over two years.<\/p>\n

\u201cMy model is that a major factor in modulating cell death is the regulation of the levels of some proteins,\u201d he explains. \u201cThis regulation of protein levels matters in determining the cell\u2019s state\u2014whether it will succumb to death or recover.\u201d<\/p>\n

Eldeeb is examining the molecular regulators of one particular protein, known as PINK1, which oversees the activity of the mitochondrion, a critical component of almost every cell in the body. Mitochondria are responsible for generating the energy cells use to carry out their respective functions. In Parkinson\u2019s, a systematic breakdown of mitochondria in brain cells reduces the production of dopamine, the chemical that\u2019s crucial for sending signals from the brain to muscles.<\/p>\n

Eldeeb uses the advanced genome-editing tool CRISPR to manipulate different proteins linked to PINK1. This process will help him identify the particular molecules involved in regulating this gene, but it generates considerable amounts of information, which calls for sophisticated computer hardware and software that will seek out meaningful patterns from this mass of data.<\/p>\n

\u201cOur project will bridge gaps in the cellular basis underlying the development of Parkinson\u2019s,\u201d he says. This type of disease modelling may lead to new directions for drugs and therapies.<\/p>\n

\u201cThe cell lines and findings generated by this project will provide a useful resource for the Parkinson\u2019s community by identifying possible targets that could be used to halt the progression of this condition.\u201d<\/p>\n

\u201cIn cancer the cells are mostly resistant, but in neurodegenerative disorders, most of the neuronal cells are susceptible to cell death.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Mohamed Eldeeb, a researcher at McGill University, is looking for molecules that regulate a crucial gene linked to the onset … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":2158,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nUnmasking molecular culprits in Parkinson\u2019s disease - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unmasking molecular culprits in Parkinson\u2019s disease - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Mohamed Eldeeb, a researcher at McGill University, is looking for molecules that regulate a crucial gene linked to the onset ... 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