{"id":2374,"date":"2019-05-14T14:32:26","date_gmt":"2019-05-14T18:32:26","guid":{"rendered":"https:\/\/parkinsonpost.com\/?p=2374"},"modified":"2019-05-14T14:32:26","modified_gmt":"2019-05-14T18:32:26","slug":"rem-sleep-behaviour-disorder-and-parkinsons","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/rem-sleep-behaviour-disorder-and-parkinsons\/","title":{"rendered":"REM sleep behaviour disorder and Parkinson\u2019s"},"content":{"rendered":"
\n
\"\"<\/figure>\n<\/div>\n

Most people with REM sleep behaviour disorder (RBD), which makes them act out their dreams, later develop Parkinson\u2019s disease or related conditions such as multiple systems atrophy or Lewy body dementia. At Western University, Dr. Penny MacDonald, a neurologist and Canada Research Chair, is using imaging technology to check for structural changes in the striatum region of the brains of people with this sleep disorder. If she finds these changes, they could be used to predict who will develop Parkinson\u2019s and start treatment before motor symptoms emerge.  <\/h4>\n

REM sleep behaviour disorder is a relatively uncommon condition during which people act out their dreams while asleep, sometimes injuring their partners or themselves. Up to 80 percent of people with this disorder later develop Parkinson\u2019s disease, multiple systems atrophy or Lewy body dementia.  <\/p>\n

At Western University, Dr. Penny MacDonald, a neurologist, uses
\nsophisticated Magnetic Resonance Imaging (MRI) technology to scan the brains of
\npeople with this sleep disorder. She\u2019s checking for differences in the striatum
\nregion and sub-regions of the brain. Her research is made possible through a Parkinson
\nCanada Pilot Project Grant funded by Pedaling
\nfor Parkinson\u2019s in honour of Dr. Robert Lorne Alexander<\/strong>, in the amount
\nof $32,984 over one year.<\/p>\n

\u201cOne of the problems is that most therapies that we\u2019ve tried to either slow, halt, or reverse Parkinson\u2019s disease are not effective,\u201d says MacDonald.<\/p>\n

Part of the difficulty is that by the time people are diagnosed,
\nresearchers estimate they have already lost 60 to 80 percent of the
\ndopamine-generating brain cells critical for motor control.<\/p>\n

\u201cIf we could find a
\nbiomarker that predicts people who will develop Parkinson\u2019s, that would allow
\nus to start trying therapies at an earlier disease stage when they might be more
\neffective,\u201d says MacDonald.<\/p>\n

MacDonald suspects that her imaging
\nstudies will show that the caudal motor portion of the striatum in people with this
\nsleep disorder is smaller and has fewer nerve endings that connect to other
\nregions of the brain. If she is correct, then this structural difference in the
\nstriatum could serve as a biomarker.  <\/p>\n

By administering an MRI, doctors
\ncould then determine who is at risk for Parkinson\u2019s and start treatment sooner.\n<\/p>\n

\u201cMaybe they (medications) would have
\ngreater efficacy before widespread loss of dopamine-producing cells occurs,\u201d
\nshe says. <\/p>\n

MacDonald earned a PhD in experimental
\npsychology before she went to medical school to become a neurologist, because
\nher first love was learning about the brain. But she thought research alone
\nwould not enable her to make a difference in this crucial field.<\/p>\n

\u201cI like to have the opportunity to
\napply the things that I know,\u201d she says.<\/p>\n

She now sees patients one day a week and spends the remainder of her time on research and teaching graduate and medical students. \u201cIt gives me more freedom to do whatever research I want, because I know that at least one day a week, I will be doing something very practical to help people, so I can be more adventurous in terms of the research that I pursue.\u201d<\/p>\n

Read about other researchers<\/a> recently funded by the Parkinson Canada Research Program by visiting the research section of archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

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