{"id":33432,"date":"2017-11-14T00:02:10","date_gmt":"2017-11-14T05:02:10","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=1383"},"modified":"2017-11-14T00:02:10","modified_gmt":"2017-11-14T05:02:10","slug":"repairing-the-transportation-system-within-our-brain-cells","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/","title":{"rendered":"Repairing the transportation system within our brain cells"},"content":{"rendered":"
\"\"

Stefano Cataldi<\/p><\/div>\n

Within every brain cell, proteins are constantly moving from one compartment to another. As new proteins are produced, others are degraded or recycled \u2013 an internal traffic system designed to keep the neurons healthy and ensure the body functions properly.<\/p>\n

If one or more proteins within those cells malfunction, however, the whole system can break down. Researchers theorize that in Parkinson\u2019s disease, an accumulation of proteins that don\u2019t get cleared away, such as clumps of alpha-synuclein, can cause dopamine-producing brain cells to die and lead to the movement disorder.<\/p>\n

At the University of British Columbia, graduate student Stefano Cataldi is studying a particular protein, called VPS35. He believes VPS35 is involved in regulating this cellular traffic flow. He\u2019s trying to identify the specific role that the protein plays in the process. Cataldi received a Quebec Research Fund on Parkinson and Parkinson Society British Columbia, two-year, $30,000 graduate student award from the Parkinson Canada Research Program to pursue this research.<\/p>\n

Cataldi, a neuroscientist, is using mouse models of Parkinson\u2019s disease to observe the way that mutated forms of VPS35, or mouse models where the gene is absent, affect movement and the symptoms of the neurodegenerative disease.<\/p>\n

\u201cWe want to know why, when this protein is altered, you have these malfunctions, and what that means in the mouse behavior,\u201d Cataldi says.<\/p>\n

If he can determine whether VPS35 is working more or less than it should be during the protein transportation process, Cataldi believes the protein might become a drug target that could either slow down or speed up the traffic jam taking place within affected brain cells.<\/p>\n

Unclogging that traffic jam early in the process of neurodegeneration, before the symptoms of Parkinson\u2019s are advanced, could preserve neurons and prevent the progression of the disease, Cataldi says.<\/p>\n

\u201cThe neuron is still alive, so we could still fix the problem before it dies,\u201d he says.<\/p>\n

Cataldi, whose background is as a pharmacologist, began studying Parkinson\u2019s disease at the University of Ferrara in his native Italy. When he moved to Vancouver to complete his PhD at UBC, Cataldi also began volunteering in the Parkinson community. That fueled his passion to continue his research into the causes of this disease.<\/p>\n

\u201cParkinson\u2019s patients don\u2019t give up. They are singing and exercising and dancing and doing whatever they can to beat this disease,\u201d Cataldi says. \u201cWhen they come to you as a scientist, they actually thank you for what you\u2019re doing. I think they are amazing people.\u201d<\/p>\n

Read about other researchers<\/a> recently funded by the Parkinson Canada Research Program by visiting the research section of archiveparkinson.thedev.ca<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Within every brain cell, proteins are constantly moving from one compartment to another. As new proteins are produced, others are … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nRepairing the transportation system within our brain cells - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Repairing the transportation system within our brain cells - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Within every brain cell, proteins are constantly moving from one compartment to another. As new proteins are produced, others are ... En savoir plus\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Parkinson Canada\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/parkinsoncanada\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-14T05:02:10+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/parkinsonpost.com\/wp-content\/uploads\/2017-11-15-02-cataldi.jpg\" \/>\n<meta name=\"author\" content=\"communications@parkinson.ca\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:site\" content=\"@ParkinsonCanada\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"communications@parkinson.ca\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/\",\"name\":\"Repairing the transportation system within our brain cells - Parkinson Canada\",\"isPartOf\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\"},\"datePublished\":\"2017-11-14T05:02:10+00:00\",\"dateModified\":\"2017-11-14T05:02:10+00:00\",\"author\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\"},\"breadcrumb\":{\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/archiveparkinson.thedev.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Repairing the transportation system within our brain cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#website\",\"url\":\"https:\/\/archiveparkinson.thedev.ca\/\",\"name\":\"Parkinson Canada\",\"description\":\"Empowering the Parkinson's community across Canada\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9\",\"name\":\"communications@parkinson.ca\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g\",\"caption\":\"communications@parkinson.ca\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Repairing the transportation system within our brain cells - Parkinson Canada","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"Repairing the transportation system within our brain cells - Parkinson Canada","og_description":"Within every brain cell, proteins are constantly moving from one compartment to another. As new proteins are produced, others are ... En savoir plus","og_url":"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/","og_site_name":"Parkinson Canada","article_publisher":"https:\/\/www.facebook.com\/parkinsoncanada\/","article_published_time":"2017-11-14T05:02:10+00:00","og_image":[{"url":"http:\/\/parkinsonpost.com\/wp-content\/uploads\/2017-11-15-02-cataldi.jpg"}],"author":"communications@parkinson.ca","twitter_card":"summary_large_image","twitter_creator":"@ParkinsonCanada","twitter_site":"@ParkinsonCanada","twitter_misc":{"\u00c9crit par":"communications@parkinson.ca","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/","url":"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/","name":"Repairing the transportation system within our brain cells - Parkinson Canada","isPartOf":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#website"},"datePublished":"2017-11-14T05:02:10+00:00","dateModified":"2017-11-14T05:02:10+00:00","author":{"@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9"},"breadcrumb":{"@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/archiveparkinson.thedev.ca\/fr\/repairing-the-transportation-system-within-our-brain-cells\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/archiveparkinson.thedev.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Repairing the transportation system within our brain cells"}]},{"@type":"WebSite","@id":"https:\/\/archiveparkinson.thedev.ca\/#website","url":"https:\/\/archiveparkinson.thedev.ca\/","name":"Parkinson Canada","description":"Empowering the Parkinson's community across Canada","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/archiveparkinson.thedev.ca\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/03860c23b3c90c09c6aade3ba61072d9","name":"communications@parkinson.ca","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/archiveparkinson.thedev.ca\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/931eabe92f8bed16e93390bff0d660ab?s=96&d=mm&r=g","caption":"communications@parkinson.ca"}}]}},"_links":{"self":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/33432"}],"collection":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/comments?post=33432"}],"version-history":[{"count":0,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/posts\/33432\/revisions"}],"wp:attachment":[{"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/media?parent=33432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/categories?post=33432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archiveparkinson.thedev.ca\/fr\/wp-json\/wp\/v2\/tags?post=33432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}