{"id":40920,"date":"2023-08-04T13:50:45","date_gmt":"2023-08-04T17:50:45","guid":{"rendered":"https:\/\/www.parkinson.ca\/?p=40920"},"modified":"2023-08-04T14:57:06","modified_gmt":"2023-08-04T18:57:06","slug":"promising-treatments-in-the-2023-parkinsons-clinical-trials","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/promising-treatments-in-the-2023-parkinsons-clinical-trials\/","title":{"rendered":"Promising treatments in the 2023 Parkinson\u2019s clinical trials pipeline"},"content":{"rendered":"<p><b><i><span data-contrast=\"none\">Note: The update provided below is for informational purposes only. Any treatments described are still in experimental stages and have not been approved by Health Canada. Please speak with your doctor for any questions regarding your treatment plan.<\/span><\/i><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">New therapies progress through the clinical trials testing pipeline each year with the goal of improving the quality of life for people with Parkinson\u2019s and, ultimately, finding a cure. An overview of the current clinical trials pipeline for Parkinson\u2019s was recently published and we are here to summarize the key highlights. For a refresher on clinical trials and what happens in each phase, <\/span><a href=\"https:\/\/archiveparkinson.thedev.ca\/getinvolved\/participate-in-research-studies\/frequently-asked-questions\/\"><span data-contrast=\"none\">here is a helpful FAQ.<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Of the drugs currently being tested, seventy-six (55%) were geared for symptom management (ST), and sixty-three (45%) were disease-modifying therapies (DMTs), aimed at altering the course of Parkinson\u2019s disease progression \u2013 an upgrade from 55 DMTs last year.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"1\"><span data-contrast=\"none\">Phases of Trials<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/h3>\n<p><b><span data-contrast=\"none\">As of June 2023, there are nearly 139 Parkinson\u2019s therapies active in the clinical trial pipeline:<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">47 products in Phase I<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">72 products in Phase II<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">20 products in Phase III<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"> <img loading=\"lazy\" class=\"alignnone wp-image-40921 \" src=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto.jpg\" alt=\"DMT vs ST by Clinical Trial Phase\" width=\"655\" height=\"366\" srcset=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto.jpg 841w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto-300x168.jpg 300w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto-700x391.jpg 700w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto-150x84.jpg 150w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto-768x429.jpg 768w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtphoto-100x56.jpg 100w\" sizes=\"(max-width: 655px) 100vw, 655px\" \/><\/span><\/p>\n<p><span data-contrast=\"none\">There\u2019s a range of drugs to treat Parkinson\u2019s at various stages of the trial pipeline. The road ahead is looking positive with numerous therapeutic options being added every year.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Of the 47 treatments included in the Phase I pipeline, there was almost a 50\/50 split between disease-modifying agents and symptom-management therapies. <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">While many of the treatments in 2023 clinical trials are novel drugs being tested, most Phase II trials are repurposed drugs, meaning researchers use drugs that have already been approved to treat one condition and test this drug for the treatment of Parkinson\u2019s. One huge advantage of drug repurposing is the safety of the drug has already been established, eliminating the need to start from scratch which would be more costly and take much longer. There are currently a total of 72 products in Phase II trials, with 35% being repurposed drugs, including a drug that was initially used as an anti-epileptic and is now being repurposed for Parkinson\u2019s.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Within the Phase III pipeline, there are 20 products with the majority (14 trials) being symptom management drugs. Overall, most of the trials involving novel agents launched in either Phase I or II but it was exciting to see four trials graduate to Phase III including three DMTs. <\/span> <span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"1\"><span data-contrast=\"none\">Disease-modifying therapies<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\"> (DMTs)<\/span><\/h3>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"> <img loading=\"lazy\" class=\"alignnone wp-image-40923 \" src=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-679x700.png\" alt=\"DMT Drugs in Clinical Trail Pipeline 2023 piechart\" width=\"632\" height=\"652\" srcset=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-679x700.png 679w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-291x300.png 291w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-146x150.png 146w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-768x791.png 768w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-100x103.png 100w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs-890x917.png 890w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmtdrugs.png 988w\" sizes=\"(max-width: 632px) 100vw, 632px\" \/><\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"> <img loading=\"lazy\" class=\"alignnone wp-image-40927 \" src=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch.png\" alt=\"Stem Research\" width=\"780\" height=\"451\" srcset=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch.png 1252w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch-300x173.png 300w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch-700x405.png 700w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch-150x87.png 150w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch-768x444.png 768w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch-100x58.png 100w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/stemresearch-890x515.png 890w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><\/span><\/p>\n<p><span data-contrast=\"none\">Since 2020, the proportion of DMT trials has risen from 39.3% to 45.3%. We see a wide range of therapeutic targets within the DMT category \u2013 from therapies aimed at genetic forms of Parkinson\u2019s, to medications focused on the accumulation of the Parkinson\u2019s protein alpha-synuclein, to probiotics for gut health. In 2023<\/span><span data-contrast=\"none\">,<\/span><span data-contrast=\"none\"> we see increased activity in the cell therapy space with six stem cell trials. <\/span><span data-contrast=\"auto\">The increased spotlight on stem cell therapy in recent years represents a shift in the therapeutic landscape and offers another avenue to potentially stop or slow the progression of Parkinson\u2019s.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Excitingly, three DMT trials in Phase III are scheduled to be completed by the end of 2023.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Phase 3 DMT trials completing in 2023:<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"auto\">Memantine<\/span><\/i><i><span data-contrast=\"none\">:<\/span><\/i><span data-contrast=\"none\"> Alzheimer\u2019s drug that aims to reduce cognitive impairment in Parkinson\u2019s.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"auto\">Ganoderma\/Lingzh<\/span><\/i><i><span data-contrast=\"none\">:<\/span><\/i><span data-contrast=\"none\"> Mushrooms from traditional Chinese medicine are being studied for their potential to slow the progression of Parkinson\u2019s symptoms.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">Buntanetap:<\/span><\/i><span data-contrast=\"none\"> Reduces the production of alpha-synuclein with the goal of improving motor symptoms of Parkinson\u2019s.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<h3><strong>Symptom therapies and their targets\u00a0<\/strong><\/h3>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"> <img loading=\"lazy\" class=\"alignnone wp-image-40925 \" src=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets.png\" alt=\"Symptom Therapeutic Drugs and Targets \" width=\"759\" height=\"463\" srcset=\"https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets.png 1380w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-300x183.png 300w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-700x427.png 700w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-150x92.png 150w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-768x469.png 768w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-100x61.png 100w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-890x543.png 890w, https:\/\/archiveparkinson.thedev.ca\/wp-content\/uploads\/dmttargets-1264x771.png 1264w\" sizes=\"(max-width: 759px) 100vw, 759px\" \/><\/span><\/p>\n<p><i><span data-contrast=\"auto\">*Numbers in brackets indicate the number of trials focused on this symptom in the 2023 pipeline<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Of the 76 active trials for symptom management, the majority were targeted toward the management of motor symptoms (22 trials). Although some drugs (17 trials), targeted the combination of motor and non-motor symptoms, it\u2019s clear we need to see more efforts towards the management of non-motor symptoms. Additionally, people living with Parkinson\u2019s have expressed the desire for more drugs to combat the tremor symptom in the earlier stages.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"1\"><span data-contrast=\"none\">Conclusion<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">In 2023, there are 89 trials with a completion date set for the end of the year. The increasing number of trials in the pipeline highlights the efforts of the Parkinson\u2019s community, and the resilience and determination to produce more rigorous science in the face of a global pandemic. There is much to be excited about, and we look forward to the updates the year will bring.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Note: The update provided below is for informational purposes only. Any treatments described are still in experimental stages and have &#8230; <a href=\"https:\/\/archiveparkinson.thedev.ca\/fr\/promising-treatments-in-the-2023-parkinsons-clinical-trials\/\" class=\"more-link\">En savoir plus<\/a><\/p>\n","protected":false},"author":90,"featured_media":40933,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[237,246],"tags":[265,264],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Promising treatments in the 2023 Parkinson\u2019s clinical trials pipeline - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Promising treatments in the 2023 Parkinson\u2019s clinical trials pipeline - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Note: The update provided below is for informational purposes only. Any treatments described are still in experimental stages and have ... 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Any treatments described are still in experimental stages and have ... 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