{"id":809,"date":"2015-12-15T12:04:53","date_gmt":"2015-12-15T17:04:53","guid":{"rendered":"http:\/\/parkinsonpost.com\/?p=809"},"modified":"2015-12-15T12:04:53","modified_gmt":"2015-12-15T17:04:53","slug":"chelsie-kadgien-is-tracking-the-transportation-gene","status":"publish","type":"post","link":"https:\/\/archiveparkinson.thedev.ca\/fr\/chelsie-kadgien-is-tracking-the-transportation-gene\/","title":{"rendered":"Chelsie Kadgien is tracking the transportation gene"},"content":{"rendered":"
\"Chelsie

Chelsie Kadgien<\/p><\/div>\n

Discovering the function of specific genes is a critical step in the search for the cause of Parkinson\u2019s disease. \u00a0At the University of British Columbia, neuroscientist Chelsie Kadgien focuses on a particular gene called VPS35 that, when mutated, causes late-onset Parkinson\u2019s.<\/p>\n

Using a thin layer of brain cells grown on a glass culture, Kadgien, a PhD student, investigates the function of VPS35. So far, she and her colleagues believe this gene is involved in transporting proteins within brain cells. Some of the other proteins that VPS35 moves around are important links in the way brain cells communicate \u2013 a critical function that keeps the cells, and the entire brain, healthy.<\/p>\n

\u201cNeurons have an ideal amount of communication that they receive from other cells,\u201d Kadgien says. If brain cells don\u2019t get enough communication, they can die. If they get too much, they use up so much energy trying to interpret that communication that they become exhausted, which can also kill them.<\/p>\n

Kadgien believes brain cells that contain mutant forms of VPS35 have too many receptors on their surface, causing them to receive too much communication. If she can confirm her theory, using not only cell cultures, but animal models, she will open up avenues for new drugs that might disrupt or correct this particular pathway in the brain that is damaging communication and killing brain cells.<\/p>\n

\u201cWe want to understand how this particular mutation is affecting cells,\u201d she says. \u201cIdeally, we would like to find a good target for a therapeutic intervention.\u201d Kadgien recently received a two-year, $30,000 graduate student award from PSC\u2019s National Research Program, which will help fund her research project.<\/p>\n

Kadgien\u2019s interest in Parkinson\u2019s disease began when she interviewed people with dementia and their caregivers as part of her work on a B.C. study on medication for neurodegenerative diseases. \u201cI got really frustrated with my lack of ability to help those people,\u201d she says. \u201cThey would call me looking for some sort of hope, and there wasn\u2019t really anything I could give them.\u201d<\/p>\n

So Kadgien decided to focus her energy on biological research to develop a solution. One of her grandmothers and a grandfather had different forms of dementia, so she has also seen the effects first-hand. \u201cI find it very motivating,\u201d she says.<\/p>\n

Read about other researchers<\/a> funded this year by PSC\u2019s National Research Program.<\/p>\n","protected":false},"excerpt":{"rendered":"

Discovering the function of specific genes is a critical step in the search for the cause of Parkinson\u2019s disease. \u00a0At … En savoir plus<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[237],"tags":[],"yoast_head":"\nChelsie Kadgien is tracking the transportation gene - Parkinson Canada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chelsie Kadgien is tracking the transportation gene - Parkinson Canada\" \/>\n<meta property=\"og:description\" content=\"Discovering the function of specific genes is a critical step in the search for the cause of Parkinson\u2019s disease. \u00a0At ... 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